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Best Weight Loss Programs

Compare the ranked products, specifications, ratings and available buying options in this guide.

Published See the picks

Scores and product facts reflect the dated comparison snapshot. See how we rank.

  1. Best Overall
    1Noom Med
    10.0 / 10Reference score
    • methodology: Comprehensive personalized approach to weight loss and diabetes management that includes access to prescription GLP-1 medications including an oral option, support, and monitoring
    • support: Nutrition coaching, exercise guidance, behavioral therapy, access to a community of other users
    • fsa-hsa-accepted: Yes
    • plans: Monthly, 3 months
    • rx-support: Yes
    Official site
  2. 2Ro
    9.9 / 10Reference score
    • methodology: Lose weight by pairing revolutionary medication with coaching, care, and healthy lifestyle changes
    • support: On-demand provider access via video or messaging, medication management, and ongoing refill support
    • fsa-hsa-accepted: No
    • plans: Monthly
    • rx-support: Yes
    Official site
  3. 3Noom Microdose Program
    9.8 / 10Reference score
    • methodology: Comprehensive personalized approach to weight loss that includes access to low-dose prescription GLP-1 medication.
    • support: Nutrition coaching, exercise guidance, behavioral therapy, access to a community of other users
    • fsa-hsa-accepted: Yes
    • plans: Monthly, 3 Months
    • rx-support: Yes
    Official site
  4. 4TrimRx
    9.7 / 10Reference score
    • methodology: Medication-supported weight loss with dedicated physician support
    • support: Unlimited phone and text support
    • fsa-hsa-accepted: Yes
    • plans: Monthly subscription
    • rx-support: Yes
    Official site
  5. 5Sesame
    9.6 / 10Reference score
    • methodology: Diet and lifestyle guidance with a licensed doctor, personalized GLP-1 medication for eligible patients
    • support: Video appointments and unlimited messaging with your doctor for ongoing support
    • fsa-hsa-accepted: Yes
    • plans: Monthly
    • rx-support: Yes
    Official site
  6. 6Mayo Clinic Diet
    9.3 / 10Reference score
    • methodology: Personalized structure and support to achieve weight loss with GLP-1 medication
    • support: 24 weeks of education, group coaching, community support
    • fsa-hsa-accepted: Yes
    • plans: Monthly, 3 months, 12 months
    • rx-support: Yes
    Official site
  7. 7Shed
    9.0 / 10Reference score
    • methodology: Personalized health coaching, medically assisted weight loss for eligible patients
    • support: Anytime text support with your health coach
    • fsa-hsa-accepted: Yes
    • plans: Monthly subscription
    • rx-support: Yes
    Official site
  8. 8Mochi Health
    9.0 / 10Reference score
    • methodology: GLP-1 medication for weight loss with personalized care
    • support: Unlimited video visits with licensed providers and dietitians plus 24/7 care team access
    • fsa-hsa-accepted: Yes
    • plans: Monthly
    • rx-support: Yes
    Official site
  9. 9Harbor
    9.0 / 10Reference score
    • methodology: Personalized weight loss with physician-supervised program
    • support: 24/7 physician access via patient portal; registered dietitian nutrition support
    • fsa-hsa-accepted: Yes
    • plans: Monthly subscription from $99/mo
    Official site
  10. 10Brightmeds
    8.9 / 10Reference score
    • methodology: Personalized weight loss program with medication support and one-on-one check-ins
    • support: Doctor consultation and ongoing support online
    • fsa-hsa-accepted: Yes
    • plans: Personalized 1 and 3 month plans available
    • rx-support: Yes
    Official site

Our Top Choice

Best Overall
1Noom Med
10.0 / 10Reference score
  • methodology: Comprehensive personalized approach to weight loss and diabetes management that includes access to prescription GLP-1 medications including an oral option, support, and monitoring
  • support: Nutrition coaching, exercise guidance, behavioral therapy, access to a community of other users
  • fsa-hsa-accepted: Yes
  • plans: Monthly, 3 months
  • rx-support: Yes
Official site

Compare Features

ServiceBest Overall—. Noom MedNoom MedNoom Medofficial destination requires review—. RoRoRoofficial destination requires review—. Noom Microdose ProgramNoom Microdose ProgramNoom Microdose Programofficial destination requires review—. TrimRxTrimRxTrimRxofficial destination requires review—. SesameSesameSesameofficial destination requires review
methodologyComprehensive personalized approach to weight loss and diabetes management that includes access to prescription GLP-1 medications including an oral option, support, and monitoringLose weight by pairing revolutionary medication with coaching, care, and healthy lifestyle changesComprehensive personalized approach to weight loss that includes access to low-dose prescription GLP-1 medication.Medication-supported weight loss with dedicated physician supportDiet and lifestyle guidance with a licensed doctor, personalized GLP-1 medication for eligible patients
supportNutrition coaching, exercise guidance, behavioral therapy, access to a community of other usersOn-demand provider access via video or messaging, medication management, and ongoing refill supportNutrition coaching, exercise guidance, behavioral therapy, access to a community of other usersUnlimited phone and text supportVideo appointments and unlimited messaging with your doctor for ongoing support
fsa-hsa-acceptedYesNoYesYesYes
plansMonthly, 3 monthsMonthlyMonthly, 3 MonthsMonthly subscriptionMonthly
rx-supportYesYesYesYesYes

HOW WE RANK

PickGuides preserves dated product facts, reference scores and reviewed destinations in each published version. Authorized comparison pages may use documented automatic checks; commercial relationships do not replace factual validation.
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